Space Shuttle Columbia (NASA Orbiter Vehicle Designation: OV-102) was the first spaceworthy Space Shuttle in NASA's orbital fleet. First launched on the STS-1 mission, the first of the Space Shuttle program, it completed 27 missions before disintegrating during re-entry on February 1, 2003 near the end of its 28th, STS-107. The destruction of the orbiter killed all those on board.
Among those who were killed was the first Israeli astronaut Ilan Ramon. His eldest son, Asaf Ramon, died on September 13, 2009, aged 21, during a routine training flight while piloting his F-16A, 3 months after graduating from the IAF flight school as the top cadet in his class. I personally heard his plane fly over my town on its way to crash- we only found out later what it was on the news.
The Columbia crew